1. G-quadruplex is a special structure formed by telomere. 四联体是端粒形成的一种特殊的结构。
2. In this review, the possible biological roles of G-quadruplexes and the development of G-quadruplex-interactive compounds as anti-cancer drugs were highlighted. 本文综述了G四链体可能的生物学作用以及作为抗肿瘤药物潜在靶点能与其相互作用的化合物的研究与开发。
3. G-quadruplex plays a very important role in inhibiting the activity of telomerase that has close relation with cellular malignant transformation and maintaining cellular division and proliferation. 端粒酶与肿瘤细胞恶性转化、分裂、增殖密切相关,而稳定G-四链体可以有效抑制端粒酶的活性。